For any natural number n, let Δ(n) be the size of the smallest set B of integers such that every natural number from 1 to n is expressible as a difference of two elements of B (such sets are known as difference bases for the interval {1,…,n}). Write C(n):=Δ2(n)/n, and C:=infn≥1C(n). Establish upper and lower bounds on C that are as strong as possible.